Major Depression Disorder (MDD) is one of the most common mental illnesses in the US. According to the National Institue of Health, in 2020, the disorder affected roughly 21 million (8.4%) adults in the US. Prevalence of MDD is highest amongst those aged 18-25 and is higher among adult females compared to males. For some patients suffering from MDD, the disorder may impact one's quality of life and interfere with carrying out daily tasks. Depression can also lead to seizures by causing sleep deprivation. The relationship between depression and epilepsy is bidirectional.

Currently many treatment options for both MDD and Epilepsy exist including psychotherapy, pharmacotherapy, electroconvulsive therapy and bright light therapy. Treatment choice for patients should be individualized and coordinated with an interprofessional healthcare team for better outcomes. Selecting an effective compounded medication treatment for depression seizures may help improve symptoms based on specific needs of each patient.